Like any substance, diisocyanates are safe to use when the chemicals are handled in accordance with appropriate risk management and safety measures. It is also important to note that diisocyanates are practically not found in finished products. Diisocyanates are only used as a result of chemical reagents; they react with the polyol to form the PU product and are consumed during the reaction.
Also, when working with chemicals such as adhesives and sealants, safety precautions are important to protect the health and safety of users.
When applying polyurethane products, users may be exposed to trace amounts of unreacted monomeric diisocyanates that were used in the production of such prepolymers. However, once cured, the final compounds are completely free of these reactive chemicals.